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In doing this research I wanted to understand more about Lipitor as a drug. The diseases it treats, its chemical components and its medical benefits. In addition to that I also wanted to know the toxicological and physiological effects on human body, its drawbacks and also look into its specific medical documents.
According to Macmillan (2006), “drug can be best defined as substance used in the diagnosis, treatment, or prevention of a disease or as a component of a medication” (p. 302). Lipitor whose generic name is atorvastatin (Webster, 2009) is a synthetic lipid-lowering agent. It is an oral drug that lowers the level of cholesterol in blood. It belongs to a class of drugs referred to as statins, thus Lipitor is classified as a drug (Smith and Knapp, 1972). This research was intended to best understand the drug Lipitor. How it works and generally gets some vital information about the drug so that at the end of this research I can have a vivid understanding of its expected effects.
Materials and methods
This research was done by going through medical books and online journals medical articles. I also requested for clarification from Medical personnel who were of so much help as far as how the drug generally works is concerned and its side effects. I interviewed some patients that were under Lipitor dosage and also patients that have been treated using Lipitor dosage before. I also got information from the information printed on its pack.

In my research I found out that The main ingredient in Lipitor is a chemical known as atorvastatin which is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme(Roberts, 2012). This enzyme catalyzes the conversion of HMG-CoA to mevalonate is catalyzed by this enzyme which in cholesterol biosynthesis is an early and rate-limiting step. Atorvastatin calcium has an empirical formula of (C33H34FN2O5)2Ca•3H2O with a molecular weight of 1208.43. (Webster, 2009).
Atorvastatin which is the main ingredient in Lipitor works to lower cholesterol levels just like all other statins. It can also be said that Lipitor competitively inhibits HMG-CoA reductase (Webster, 2009). Lipitor works in a manner that it inhibits an enzyme in the human body that is very essential for the production of cholesterol (Roberts, 2012). Over time this the cholesterol levels in the blood to drop significantly due to these inhibiting effects. Lipitor is also used to help reduce the risk of having a heart attack or stroke in people who have high blood pressure and coronary heart disease (CHD) or who are at risk of CHD (Smith and Knapp, 1972).
It was found that Lipitor tablets that are used for oral administration contains the following: 10, 20, 40, or 80 mg atorvastatin and many inactive ingredients such as : Opadry White YS-1-7040 (hypromellose, polyethylene glycol, lactose monohydrate, NF; talc, titanium dioxide); polysorbate 80, NF; simethicone emulsion; calcium carbonate, USP; candelilla wax, FCC; croscarmellose sodium, NF; hydroxypropyl cellulose, NF;; magnesium stearate, NF; microcrystalline cellulose, NF. (Roberts, 2012)

When one uses Lipitor it leads to decreased elimination of atorvastatin that could increase levels of atorvastatin in the body and thereby increasing the risk of muscle toxicity from atorvastatin. Therefore, it is recommended that atorvastatin should not be combined with other drugs that decrease its elimination (Roberts, 2012). An example of such a drug is erythromycin (E-Mycin). Other than this Lipitor is associated with unexplained muscle pain, tenderness, or even weakness where one just feels so weak all over sudden. It is also associated with unusual tiredness fever and urine that is dark in color. In addition to these it is also associated with swelling, irregular urinating where one urinates less or even doesn’t urinate at all and also leads to weight gain. Among these side effects Lipitor also causes nausea, itching, clay-colored stool, yellowing of the skin and upper stomach pain. Other than the above mentioned Lipitor can cause serious muscle problems that can lead to kidney problems, including kidney failure and liver problems. (Smith and Knapp, 1972) Lipitor has so many benefits since it is a prescription medicine that lowers cholesterol in your blood. It helps to lowers the (“bad” cholesterol) and triglycerides in your blood thus making them to be in quantities so that they do not pose any health risk (Roberts, 2012). It can also raise your HDL-C (“good” cholesterol) as well, this is also very much recommended health wise. Lipitor is for people whose cholesterol does not come down enough when they do a lot of exercise and when they also take meals that are low in fat (Smith and Knapp, 1972).
. Lipitor also help to lower the risk of one getting an heart attack, stroke or even chest pain in patients who have heart diseases are exposed to risk factors for heart disease such as age, smoking, hereditary heart disease. (Webster, 2009)
Lipitor as a drug has quite a number of draw backs which in one way or the other really hinder its proper usage. For example Lipitor should not be taken by women who are pregnant or are thinking that they could be pregnant, or in one way or the other are planning to become pregnant (Roberts, 2012). This is because Lipitor could turn out to be very harmful to the unborn baby. If one gets pregnant, he or she is advised to stop taking stop taking Lipitor. The mothers who are breast feeding should also not use Lipitor since the content of the drug can pass into her breast milk and may harm the baby (Roberts, 2012). Lipitor cannot also be taken by those who are allergic to any of Lipitor’s ingredient. (Dr. E. Robbins, personal communication, October 18, 2012).
In my opinion Lipitor is quite a medical success since it has helped to solve quite a good number of medical complications. So I advice that one should obey the medical advice that come with it and one will surely acknowledge the benefits of treating him/herself with this drug.


Roberts, B. H. (2012). The truth about statins: risks and alternatives to cholesterol-lowering drugs. New York: Gallery Books.
Smith, M. C., & Knapp, D. A. (1972). Pharmacy, drugs, and medical care. Baltimore: Williams & Wilkins C.
Webster, M. (2009). Drugs. Farmington Hills, MI: Greenhaven Press/Gage Cengage.…...

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